One main function of bikunin is to inhibit serine protease, especially elastase, and to suppress neutrophils, lymphocytes and macrophages increased by infection and inflammation ( 11). In 1955, the protein responsible for the antitrypsin activity of urine, bikunin, was isolated ( 10). One hundred years ago it was reported that human urine had the capacity to inhibit trypsin ( 10). The purpose of this study was to investigate the anti-inflammatory effects of ulinastatin on proinflammatory cytokines and PMNE in trauma patients suffering from hemorrhagic shock. In animal studies, the effects of ulinastatin on artificially induced hemorrhagic shock have been reported ( 8, 9), but studies about inflammatory cytokines or PMNE and clinical trials of hemorrhagic shock in humans have not been reported. Ulinastatin, a glycoprotein with a molecular weight of 67,000 daltons derived from human urine, has anti-inflammatory activity which may suppress PMNE, TNF-α, IL-6, IL-8 ( 5- 8). ( 4) revealed protective effects of IL-6 blockade in sepsis. Levels of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α) and polymorphonuclear leukocyte elastase (PMNE) begin to increase in early inflammation, stimulating various tissues and organs and leading to a systemic inflammatory response. Multiple organ failure is the leading cause of mortality after hemorrhagic shock ( 1- 3). These systemic metabolic changes can lead to acute respiratory distress syndrome and microischemia of the liver, and can impair functions of the kidney, heart and brain. This damage occurs during the resuscitation period, when neutrophils become active and inflammatory cytokines increase in both hemorrhagic shock and systemic inflammation (i.e. Shock resulting from hemorrhage induces life-threatening ischemic injuries in organs as well as tissues. It is suggested that ulinastatin treatment could decrease the serum PMNE levels in trauma patients with hemorrhagic shock at 48 hr after treatment. Serum TNF-α and IL-6 levels in the ulinastatin group decreased 24 hr after admission but had no significance. The serum PMNE levels in the ulinastatin group were lower than in the control group on the second hospitalized day. There were no significant differences in baseline values, laboratory data, treatment or mortality between the two groups. We compared the Systemic Inflammatory Response Syndrome scores, Multiple Organ Dysfunction Syndrome scores and Acute Physiology, age, Chronic Health Evaluation III scores of the control and ulinastatin groups. Measurements of serum PMNE, TNF-α and IL-6 were taken before ulinastatin treatment at 24 hr, two days, three days, and seven days after admission. Eleven patients were randomly selected to receive a total of 300,000 IU of ulinastatin. Nineteen patients who visited the emergency department for traumatic hemorrhagic shock were enrolled. KYNG wrapped up 2013 with the Hellpop tour with IN THIS MOMENT, MOTIONLESS IN WHITE and ALL HAIL THE YETI and will hit the road in 2014 to support of 'Burn The Serum'.We investigated the use of ulinastatin in association with the suppression of polymorphonuclear leukocyte elastase (PMNE), tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6), and its effects on the prognosis of patients with traumatic hemorrhagic shock. They hit the road with everybody from THE SWORD and CLUTCH to TRIVIUM and MEGADETH even being picked to play at METALLICA's first-ever Orion Music + More festival. The album landed shining critical acclaim for its 'California heavy' sound, merging the metallic meanderings of SOUNDGARDEN and QUEENS OF THE STONE AGE with the timeless scope of BLACK SABBATH and LED ZEPPELIN. Formed in 2008, KYNG broke out of the City of Angels in 2011 with the group's independent debut, 'Trampled Sun'. The Los Angeles outfit may only boast three members Eddie Veliz (vocals/guitar), Pepe Clarke (drums) and Tony Castaneda (bass/backup vocals) but their collective roar could easily tip the Southern California Richter scale.

At the same time, they keep their eyes wide open towards the future. On its second full-length album and first for Razor & Tie, KYNG harks back to the essence of heavy rock 'n' roll, forging thunderous percussion to lightning hot riffs driven by a divine vocal howl. The 'Burn The Serum' cover artwork can be seen below. and Sword & Shield in Hollywood, California as well as at Studio 606 in Northridge, California. Rota and was recorded at Grandmaster Recorders Ltd. The CD was produced by Andrew Alekel ( FOO FIGHTERS, NO DOUBT, QUEENS OF THE STONE AGE, CLUTCH) and James A. Southern California rock trio KYNG will release its new studio album, 'Burn The Serum', on April 15 via Razor & Tie.

Kyung burn the serum torrent